Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo. The recommended starting Zoloft dose for people with depression or obsessive-compulsive disorder (OCD) is Zoloft 50 mg once a day. Your healthcare provider may choose to increase the dosage if symptoms continue, or decrease it if side effects occur. The recommended starting dose of Zoloft for people with panic disorder, post-traumatic stress disorder (PTSD), or social anxiety disorder is Zoloft 25 mg once a day. After a week, your healthcare provider will likely increase the dose to 50 mg of Zoloft once a day. He or she may also choose to increase the Zoloft dosage if symptoms continue, or decrease the dose if side effects occur. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click In order for us to create your customized Health Savvy programs, we need a little more information about the health topic(s) that you are interested in. Azithromycin uti Safe website to buy clomid How can i buy aciclovir tablets for cold sores A very high dosage of sertraline of 400 mg/day has been found to produce peak plasma concentrations of about 250 ng/mL 816 nM. This can be estimated to result in a free concentration of 3.75 ng/mL 12.2 nM, which is still only about half of the K i of sertraline for the DAT. Initial dose 50 mg orally once a day during the menstrual cycle-Maintenance dose 50 to 150 mg orally once a day during the menstrual cycle Cyclic regimen-Initial dose 50 mg orally once a day starting 14 days prior to the anticipated start of menstruation through to the first full day of menses, and repeated with each new cycle The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below. A dosage of. Sertraline oral tablet is a prescription drug that’s available as the brand-name drug Zoloft. This drug may be used as part of a combination therapy. In some cases, they may not be available in every strength or form as the brand-name version. This drug is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. This means you may need to take it with other medications. This drug belongs to a class of drugs called selective serotonin reuptake inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. This drug works by increasing the amount of serotonin, a natural substance in your brain, that helps maintain mental health balance. A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as sertraline during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. You should know that your mental health may change in unexpected ways when you take sertraline or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; new or worsening anxiety; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Sertraline dose Sertraline Zoloft Side Effects, Dosages, Treatment., Sertraline Dosage Guide with Precautions - Propranolol brand nameViagra 4 hours Sertraline Zoloft is an oral medication used to treat major depressive disorder and other disorders. Learn about side effects, warnings, dosage, and more. Sertraline Side Effects, Dosage, Uses & More. ZOLOFT® sertraline HCl Dosage and Administration Pfizer Medical.. Zoloft sertraline dosing, indications, interactions, adverse effects, and.. See risks & benefits. Learn more about ZOLOFT® sertraline HCl, a prescription treatment for depression. Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors SSRIs. MISSED DOSE If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.