Sertraline effectiveness

Discussion in 'Canadapharmacy' started by lkisd, 08-Sep-2019.

  1. Osip New Member

    Sertraline effectiveness


    Sertraline Tablets is indicated for the treatment of symptoms of depressive illness, including accompanying symptoms of anxiety. Following satisfactory response, continuation with Sertraline Tablets therapy is effective in preventing relapse of the initial episode of depression or recurrence of further depressive episodes, including accompanying symptoms of anxiety. Sertraline Tablets is also indicated for the treatment of obsessive-compulsive disorder (OCD). Following initial response, Sertraline Tablets has been associated with sustained efficacy, safety and tolerability in up to two years treatment of OCD. Clinical trials in PTSD demonstrated efficacy in female patients but no evidence of efficacy was seen in males. Treatment with Sertraline Tablets cannot normally therefore be recommended for male patients with PTSD. A therapeutic trial in males might on occasion be justified, but treatment should subsequently be withdrawn unless there is clear evidence of therapeutic benefit. I confronted this question last September, when I had breakfast with one of psychiatry's leading scholars and administrators. He was complaining about the influence of pharmaceutical houses on physicians. Why, he asked, did doctors prescribe the newer antipsychotics, like Abilify and Zyprexa, when studies showed that older and much cheaper drugs, like Trilafon and Haldol, were just as effective? I told my colleague that I shared his concern about the influence of drug companies, but I thought that clinicians had a tough choice. The side effects of the medications were so different that the new and old medications were finally not identical. All right, the colleague said, but what about antidepressants? Almost all those medications are available as generics, but at a disproportionate rate, doctors prescribe the one antidepressant that still has patent protection, Lexapro.

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    BACKGROUND Few treatment options are available for children and adolescents with major depressive disorder due to a lack of efficacy data, particularly with. Sertraline, a selective serotonin reuptake inhibitor SSRI, treats disorders such as depression, panic disorder, post-traumatic stress disorder PTSD. Goals of work Cancer is often burdened by psychological comorbidity, mainly represented by depression, anxiety and adjustment disorders. Efficacy and.

    , loss of functioning and productivity, and creates significant demands on service providers in terms of workload. Although pharmacological and psychological interventions are both effective for major depression, antidepressant drugs remain the mainstay of treatment. During the last 20 years, selective serotonin reuptake inhibitors (SSRIs) have progressively become the most commonly prescribed antidepressants. Sertraline, one of the first SSRIs introduced in the market, is a potent and specific inhibitor of serotonin uptake into the presynaptic terminal, with a modest activity as inhibitor of dopamine uptake. Outcomes of clear relevance to patients and clinicians, in particular, patients and their carers' attitudes to treatment, their ability to return to work and resume normal social functioning, were not reported in the included studies. Nevertheless, based on currently available evidence, results from this The National Institute for Health and Clinical Excellence clinical practice guideline on the treatment of depressive disorder recommended that selective serotonin reuptake inhibitors should be the first-line option when drug (1974 to 2008), the Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register and the Cochrane Central Register of Controlled Trials up to July 2008. Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo.

    Sertraline effectiveness

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    Sertraline, sold under the trade name Zoloft among others, is an antidepressant of the selective. Sertraline is effective for the treatment of OCD in adults and children. It was better tolerated and, based on intention to treat analysis, performed. Following satisfactory response, continuation with Sertraline Tablets therapy is effective in preventing relapse of the initial episode of depression or recurrence of. ELSEVIER Journal of Affective Disorders 38 1996 97-1 JOURNAL OF AFFECTIVE DISORDERS Research report A comparison of the cost-effectiveness of sertraline.

     
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