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    1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, 50 mg tablets; 5 mg/5 m L, 5 mg/m L solution Immediate-acting synthetic analog of hydrocortisone. Effect depends on biotransformation to prednisolone, a conversion that may be impaired in patient with liver dysfunction. Less mineralocorticoid activity than hydrocortisone, but sodium retention and potassium depletion can occur. May be used as a single agent or conjunctively with antineoplastics in cancer therapy; also used in treatment of myasthenia gravis and inflammatory conditions and as an immunosuppressant. Systemic fungal infections and known hypersensitivity; pregnancy (category C), lactation. Patients with infections; nonspecific ulcerative colitis; diverticulitis; active or latent peptic ulcer; renal insufficiency; hypertension; osteoporosis; myasthenia gravis. Prednisolone 5 mg tablet; 5 mg/5 m L, 15 mg/5 m L syrup, 0.12%, 0.125%, 1% ophthalmic suspension Acetate 25 mg/m L, 50 mg/m L injection Sodium Phosphate 5 mg/5 m L liquid; 20 mg/m L injection; 0.125%, 1% ophthalmic solution Tebuate 20 mg/m L injection Analog of hydrocortisone with 3–5 times greater potency. Mineralocorticoid properties are minimal, and potential for sodium and water retention as well as potassium loss is reduced. Principally as an antiinflammatory and immunosuppressant agent. Safety during pregnancy (category C) or lactation is not established.

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    Prednisone is used for many different autoimmune diseases and inflammatory conditions, including: asthma, COPD, CIDP, rheumatic disorders, allergic disorders, ulcerative colitis and Crohn's disease, adrenocortical insufficiency, hypercalcemia due to cancer, thyroiditis, laryngitis, severe tuberculosis, urticaria (hives), lipid pneumonitis, pericarditis, multiple sclerosis, nephrotic syndrome, sarcoidosis, to relieve the effects of shingles, lupus, myasthenia gravis, poison oak exposure, Ménière's disease, autoimmune hepatitis, giant-cell arteritis, the Herxheimer reaction that is common during the treatment of syphilis, Duchenne muscular dystrophy, uveitis, and as part of a drug regimen to prevent rejection after organ transplant. It is important in the treatment of acute lymphoblastic leukemia, non-Hodgkin lymphomas, Hodgkin's lymphoma, multiple myeloma, and other hormone-sensitive tumors, in combination with other anticancer drugs. Prednisone can be used in the treatment of decompensated heart failure to increase renal responsiveness to diuretics, especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics. In terms of the mechanism of action for this purpose: prednisone, a glucocorticoid, can improve renal responsiveness to atrial natriuretic peptide by increasing the density of natriuretic peptide receptor type A in the renal inner medullary collecting duct, inducing a potent diuresis. Short-term side effects, as with all glucocorticoids, include high blood glucose levels (especially in patients with diabetes mellitus or on other medications that increase blood glucose, such as tacrolimus) and mineralocorticoid effects such as fluid retention. The mineralocorticoid effects of prednisone are minor, which is why it is not used in the management of adrenal insufficiency, unless a more potent mineralocorticoid is administered concomitantly. It can also cause depression or depressive symptoms and anxiety in some individuals. Prednisone Side Effects, Dosage, Uses, and More Prednisone Sterapred - Side Effects, Dosage, Interactions - Drugs DailyMed - DELTASONE- prednisone tablet
     
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