Apo-Sertraline (CA), Co Sertraline, Dom-Sertraline, Gen-Sertraline (CA), Lustral (UK), Novo-Sertraline (CA), Nu-Sertraline (CA), PHL-Sertraline (CA), PMS-Sertraline (CA), Ratio-Sertraline (CA), Riva-Sertraline (CA), Sandoz Sertraline (CA), Zoloft • Drug may increase risk of suicidal thinking and behavior in children and adolescents with major depressive disorder (MDD) and other psychiatric disorders. Risk must be balanced with clinical need, as depression itself increases suicide risk. With patient of any age, observe closely for clinical worsening, suicidality, and unusual behavior changes when therapy begins. Advise family and caregivers to observe patient closely and communicate with prescriber as needed. • Drug isn't approved for treating MDD in pediatric patients. Panic disorder; social anxiety disorder; posttraumatic stress disorder Adults: Initially, 25 mg/day P. After 1 week, may increase to 50 mg/day; depending on response, may then increase at weekly intervals to a maximum of 200 mg/day. Use cautiously in: • seizures disorders, severe hepatic or renal impairment, increased risk for suicide • history of mania • concurrent use of serotonergic agents such as tryptophan (use not recommended) • pregnant or breastfeeding patients • children. A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as sertraline during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. You should know that your mental health may change in unexpected ways when you take sertraline or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; new or worsening anxiety; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Prednisone hiccups Buy cialis from india Legit site to buy nolvadex In response to questions, IVAX AMEXIVX today explained that its first-to-file application for sertraline hydrochloride, the generic version of Pfizer's ZoloftR, is not affected by the new rule proposed in the FDA's recently published guidance concerning commencement of the six-month market exclusivity period for first-to-file generics. Sertraline is also used for headache, premenstrual dysphoric disorder, diabetic neuropathy and premature ejaculation. Sertraline is available as tablets of 25, 50 and 100 mg and as an oral suspension in multiple generic forms and under the brand name of Zoloft. Sertraline Definition Sertraline is an antidepressant that belongs to the class of drugs called selective serotonin reuptake inhibitors SSRIs. In the in United States 1 it is sold under the brand name Zoloft. Initial: 50 mg q Day PO given continuously throughout menstrual cycle or given during luteal phase only May increase by 50 mg at the onset of each new menstrual cycle; no more than 150 mg q Day when administered continuously or 100 mg q Day when administered during luteal phase only 25 mg PO q Day initially; may increase by 25 mg every 2-3 days; not to exceed 200 mg q Day Alzheimer dementia related depression: Start at 12.5 mg/day and titrate every 1-2 weeks to response; not to exceed 150-200 mg Renal impairment: Dose adjustment not necessary Mild hepatic impairment (Child-Pugh 5-6): Decrease recommended starting dose and therapeutic dose by 50% Moderate-to-severe hepatic impairment (Child-Pugh 7-15): Not recommended; sertraline is extensively metabolized, and the effects in patients with moderate and severe hepatic impairment have not been studied Clinical worsening and suicide ideation may occur despite medication Use caution in patients with seizure disorders May worsen mania symptoms or precipitate mania in patients with bipolar disorder Increases risk of hyponatremia and impairment of cognitive/motor functions in the elderly Increases risk of bleeding in patients taking anticoagulants/antiplatelets concomitantly Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy Pregnancy: Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy) In neonates exposed to SNRIs/SSRIs late in third trimester: Risk of complications such as feeding difficulties, irritability, and respiratory problems Avoid abrupt withdrawal Bone fractures reported with antidepressant therapy; consider the possibility if patient presents with bone pain, bruising, or point of tenderness Coadministration with other drugs that enhance the effects of serotonergic neurotransmission (eg, tryptophan, fenfluramine, fentanyl, 5-HT agonists, St. John’s Wort) should be undertaken with caution and avoided whenever possible due to the potential for pharmacodynamic interaction (see Contraindications) May cause false-positive urine immunoassay screening tests for benzodiazepines SSRIs and SNRIs are associated with development of SIADH; hyponatremia reported Several SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) are metabolized by CYP2D6 CYP2D6 is involved in the metabolism of approximately 20% of drugs in clinical use and displays large individual-to-individual variability in activity due to genetic polymorphisms More than 80 CYP2D6 variant alleles have been identified; however, 4 of the most prevalent alleles, CYP2D6*3, *4, *5, and *6, account for 93-97% of CYP2D6 poor metabolizers CYP2D6*4, the most common variant (~25% frequency in whites), causes a splicing defect; CYP2D6*3 (2.7% frequency) causes a frameshift mutation; and CYP3D6*5 (2.6%) is an entire deletion of the CYP2D6 gene; individuals homozygous for these alleles have no CYP2D6 activity The impact of CYP2D6 activity is further complicated in some SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) because in addition to being substrates for CYP2D6, they are also known to moderately inhibit CYP2D6 activity The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list. Sertil (100 mg) | Alzex Forte | Serjet (100mg) | Serybest (100 mg) | Senta (100 mg) | Serne | Yline (100 mg) | Retalin (100 mg) | Sertimo -100 | Depser -Plus | Steel (100 mg) | Zoline | Yline | Inosert (100mg) | Alsert | Setal | SERTANEX-50 | Sertin (50mg) | Tralin (50 mg) | Episod (25 mg) | Setraline (100 mg) | Nexlpra -S | Zoline (100 mg) | Alzolam Plus | Serlift | Altalin | Tralin (100 mg) | Depsert (100 mg) | MCalm | Alarm - Forte This medication is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class, prescribed for major depression, obsessive-compulsive disorder, panic attacks, and social anxiety disorder. It increases the amounts of serotonin, a natural substance in the brain that helps maintain mental balance. Caution should be exercised in patients with history of hypomania and seizure disorders, liver or kidney damage, heart disease, recent heart attack, bleeding disorders, diabetes and angle-closure glaucoma. Discontinue treatment if seizures develop or if there is an increase in seizure frequency. Monitor for signs of clinical worsening, suicidality and unusual changes in behavior especially during the initial treatment period or when there are dosage adjustments. Sertraline class Dissolution profiling of Sertraline Hydrochloride Anita., Sertraline - Search Livertox Database Tamoxifen liver toxicityBuy cialis genericZoloft vyvanse Sertraline is a drug that is used to treat depression, obsessive-compulsive disorder, panic disorder, and post-traumatic stress disorder. Like other SSRIs, sertraline also is used for treating social anxiety disorder and postmenstrual dysphoric disorder. Sertraline belongs to a class of drugs called selective serotonin reuptake inhibitors SSRI. The official site for Sertraline information. Sertraline. Sertraline Wiki Everipedia. Инструкция на Сертралин Как правило, начальная дозировка для пациентов старше 12 летСертралин – селективный ингибитор обратного захвата серотонина, антидепрессант. Sertraline hydrochloride belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors SSRIs. Despite distinct structural. Sertraline oral tablet is a prescription drug that’s available as the brand-name drug Zoloft. It’s also available as a generic drug. Generic drugs usually cost less.