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    With commentary by Nir Barzilai, MD, director of the Institute for Aging Research, Albert Einstein College of Medicine, and Brian Kennedy, Ph D, president and CEO of the Buck Institute for Research on Aging. Metformin, a drug taken by many with diabetes, may have much greater potential beyond controlling blood sugar, some experts say. And accumulating data suggests that ''it interferes with the biology of aging." Aging, he says, is a primary risk factor for not only diabetes but also most of our big killers, such as Alzheimer's, heart disease and cancer. Metformin may influence fundamental aging factors that underlie many age-related conditions, including cancer, heart disease and Alzheimer's, says Nir Barzilai, MD, director of the Institute for Aging Research at Albert Einstein College of Medicine, the Bronx. In animal and human studies, metformin has shown promise in slowing the aging process and halting diseases. Barzilai plans to launch a large-scale study, Targeting Aging with METformin (TAME), to look at the effects of metformin compared to placebo. His team has already completed the MILES study, Metformin in Longevity, and are analyzing the results. In that study, they gave some participants metformin, at 1,700 milligrams a day, and others placebo. He brushed them off, saying the people who don't see the value of the research ''don't understand the biology of aging and that it can be changed." He doesn't see the research as testing an anti-aging drug. The aim was to see if the metformin could restore the gene expression profile of an older person with blood sugar problems known as impaired glucose tolerance (but not yet diabetic), to that of a younger person. "Aging is not a disease and we don't want it to be a disease," he says. However, age is a risk factor for many disabling conditions, he says. Metformin reduces the risk of cancer in patients with type 2 diabetes Risk of Cancer in Diabetes The Effect of Metformin - Hindawi Metformin Therapy and Risk of Cancer in Patients with Type 2.
     
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