Prednisone is a potent corticosteroid drug used to treat inflammatory forms of arthritis as well as some types of cancer and autoimmune disease. It's available in tablet and liquid formulations and functions as an immunosuppressant, tempering inflammation by blunting the immune response. Inflammation is the body's natural response to anything it considers harmful. When the immune system identifies a harmful agent, it releases chemicals into the bloodstream which cause tissues to swell, in part to increase the size of blood vessels and allow larger immune cells closer access to the site of an injury or infection. With certain autoimmune disorders, the immune response is abnormal and excessive. Such is the case with rheumatoid arthritis (RA), a condition where the immune system mistakenly attacks healthy joints. Acute RA symptoms often flares without notice, causing increased pain, swelling, and injury to the affected joint. When prednisone is taken for more than a few weeks, the body becomes accustomed to it and begins to make less of its natural steroids. If it is stopped too quickly, the body does not have time to adjust, and dangerous side effects can occur. Please do talk to your health care provider for more accurate info, take care, be safe & well! Rajive is right, I had a good friend who was on it constantly his body had so many problems , in February I caught a fall and it is starting to form arthritis but the doctor I go to on an ongoing basis told me it would be far better if we could use the non steroidal drugs and anti-inflammatories such as the Nsaids, But everyone is different and your physician may decide this is necessary for awhile, as he said talking with the doctor then you will get more accurate information due to your history. Please keep us posted, Laurasmithif your doctor does have you take this then the safe thing to do would be to talk with him about the possibility of reducing the dose or going off it maybe there is a possiblity that he can find a medication if he decides he needs to use this that he can make changes in. hopefully if he does have to prescribe it then he will talk to you about how he wants you to plan on discontinuing it it is my hope that this is possible, but follow his directions! please take good care and keep us posted as to how you are doing I have been off of the prednisone for a week now and I cannot breath good. I hav a tooth killing me and my pain medicine is not helping it from hurting and throbbing. Viagra precautions Buy doxycycline south africa If you need a little comic relief from the side effects of taking prednisone, check out these illustrated quotes from others who can totally relate. Prednisone is a drug that is used to treat inflammatory bowel disease IBD. Learn how. Living With Prednisone. The Side Effects Of. How long does prednisone stay in your system? it take for to clear Crohn how the body after you stop effect of treatment on half life intravenous. Prednisolone is indicated in the management of all conditions deemed likely to benefit from short or long term glucocorticoid therapy. These include: Allergic states Severe, incapacitating allergies unresponsive to conventional treatment; asthma serum sickness; drug hypersensitivity reactions. Collagen disorders Eg systemic lupus erythematosus, polymyositis, polymyalgia rheumatica and temporal (giant cell) arteritis, mixed connective tissue disease syndrome, acute rheumatic carditis. Rheumatic disorders Usually given as an adjunctive therapy for short term administration during an acute episode or exacerbation of rheumatoid arthritis, psoriatic arthritis. Skin conditions Life-threatening or incapacitating skin conditions such as pemphigus and exfoliative dermatitis. Neoplastic disease Leukaemias and lymphomas in adults, acute leukaemia of childhood. Gastro-Intestinal disease During acute exacerbation in ulcerative colitis and regional ileitis (Crohn's Disease). Prednisolone is a synthetic adrenal steroid with moderately potentiated glucocorticoid activity (approximately five times that of hydrocortisone) and less than 10% of hydrocortisone's mineralocorticoid activity. From: and prednisone exhibit concentration-dependent nonlinear pharmacokinetics when parameters are measured with reference to total drug concentration. Dose dependency disappears when free (unbound) prendisolone is measured. Altered organ function, changing biochemistry and use of a number of concomitant medicines in transplantation appear to lead to pharmacokinetic differences in transplant recipients compared with other patient groups. Time post-transplant, hepatic and renal dysfunction, patient age, sex, body weight, serum albumin concentration, concomitant medication exposure, various disease states and genetic polymorphism in metabolic enzymes and drug transporters have sometimes been associated with pharmacokinetic variability. The clinical impact of corticosteroid therapy on the disposition of cyclosporine, tacrolimus and sirolimus and the impact of different immunosuppressive therapy combinations of and prednisone therapy, but not all of these have been investigated thoroughly in transplant populations. Dyslipidaemia, growth restriction, diabetogenesis, hypertension and cataracts are well-studied toxicities. Evidence is less clear for This investigation compares clinical courses, efficacies, adverse reactions and outcome of 115 consecutive, biopsy-proven polymyositis patients treated with ADT (32 patients) or DDT (83 patients). 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