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    Antidepressants may play a key role in alleviating painful conditions like osteoarthritis and may result in fewer side effects than traditionally prescribed drugs, such as anti-inflammatories and opioids, according to new research. Researchers at New York Medical College analyzed the latest clinical evidence on duloxetine (Cymbalta), an antidepressant that received FDA approval in 2010 for use with chronic musculoskeletal pain, including osteoarthritis.“It is not uncommon to treat osteoarthritis with a combination of drugs that work in different ways,” said Leslie Citrome, M. D., clinical professor of psychiatry and behavioral sciences. “Our review supports this approach and confirms that antidepressants are not just for depression and can play a key role in relieving this painful condition.”The reseachers looked at studies exploring the effects of Cymbalta (duloxetine) on its own or in combination with non-steroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen) — including the two double-blind, placebo-controlled clinical trials that formed the basis of FDA approval for duloxetine for the treatment of chronic pain associated with osteoarthritis. Study results were analyzed using number needed to treat (NNT) and number needed to harm (NNH). These quantify how many patients need to be treated with one intervention versus another before encountering one additional patient who experiences a desired outcome (NNT) or undesired disadvantage, such as a side effect (NNH), researchers said. A smaller number indicates greater advantages for NNT and greater disadvantages for NNH.“Applying these simple methods to often complex research gives us a real indication of whether a drug will benefit or harm our patients, which is what we as clinicians are most interested in,” Citrome said. Efficacy and Safety of Duloxetine on Osteoarthritis Knee Pain A Meta. Antidepressant Cymbalta Helps Alleviate Osteoarthritis Pain Cymbalta User Reviews for Osteoarthritis at
     
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