Be very careful with prednisone, it is an extremely powerful drug that can can tons of horrible side effects and long term permanent issues. I am still fighting with adrenal problems 3 years after I needed two 5 day tapers in a month, my body and it's stress response probably will never go back to the way it was. You need to get an appointment with a specialist and figure out the root cause of the problem and not just bandaid it with the meds. I started thinking that all the Doctors were self medicating with antidepressants so they though everything was fine if you just take this little pill. I know in some cases people do need antidepressants. But I can't believe that was the opinion of every doctor that I saw. I am retired and disabled, so I thought if I changed antidepressants I could save over $200/mo, which isn't much to some, but it IS to me. My GI doc wants me to start taking prednisone (20 mg for now) and after reading up on potential side effects I'm a bit concerned about the mental health aspect. I am currently taking Zoloft (75 mg) for depression and anxiety (though the anxiety is largely unaffected by the Zoloft). Given that prednisone can cause depression/anxiety in folks not otherwise afflicted, how concerned should I be about the impact of prednisone on my mental health? I know that 20 mg isn't a very high dose, but I figure it's good to ask since I don't know what dose I may take in the future. I'll be sure to mention the prednisone to the nurse who prescribes my depression meds, but is there anything else I should do? Also, I have a problem with compulsive skin-picking (sometimes considered an OCD spectrum disorder) that is worse when my skin breaks out. If I didn't have much acne as a teenager, should I expect to get a lot of acne from prednisone? 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Unfortunately, some of the common drugs for these issues — like prednisone and other corticosteroids, and bupropion (Wellbutrin) and other antidepressants — have less-than-desirable side effects — namely: weight gain. And while you should go easy on yourself — you’re battling an illness, after all — it can be a frustrating adverse effect. Read on to find out the best ways to lose unwanted pounds brought on by medication you need. Antipsychotic drugs, antidepressants, and mood stabilizers are common drugs that have the most potential to increase weight gain. All 12 of the leading antidepressants — including fluoxetine (Prozac), sertraline (Zoloft), and escitalopam (Lexapro) — make gaining weight more likely. With approximately 13 percent of Americans currently taking antidepressants — and without medication options that don’t cause fluctuations in weight — a lot of people can’t avoid being put at higher risk for unhealthy weight gain. 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