Azithromycin vs doxycycline

Discussion in 'Pharmacy Drug Store' started by Paranoid, 30-Aug-2019.

  1. khm New Member

    Azithromycin vs doxycycline


    Doxycycline is the typical first-line treatment for acne vulgaris, but it comes with some less-than-desirable side effects such as gastrointestinal symptoms, tooth discoloration, photosensitive reactions, pigmentation changes, and central nervous system effects. In addition, doxycycline is contraindicated for children under 8 and during pregnancy. A recent study compared the use of an alternate therapy, oral azithromycin pulse therapy, directly with doxycycline to determine whether they have comparable efficacy. Azithromycin has some characteristics that may make it a better treatment option; a long half-life that is helpful for patient compliance, a better safety profile for use during pregnancy and childhood, and the main side effects are mild gastrointestinal discomfort that actually occur less frequently than with other antibiotics. The meta-analysis looked at the two medications head-to-head in multiple randomized controlled trials. The results showed that doxycycline daily therapy and azithromycin pulse therapy had similar efficacy in the treatment of moderate to severe acne vulgaris. In addition, the groups that used azithromycin reported fewer severe adverse events. The effectiveness of azithromycin and doxycycline in the treatment of erythema migrans was compared in a prospective randomized trial. One hundred seven adult patients with typical erythema migrans, examined in the Lyme Borreliosis Outpatients' Clinic, University Department of Infectious Diseases in Ljubljana, were included in the study. Fifty-five patients received azithromycin (500 mg twice daily for the first day, followed by 500 mg once daily for four days) and 52 patients received doxycycline (100 mg twice daily for 14 days). The mean duration of skin lesions after the beginning of treatment was 7.5±5.9 days (median value 5, range 2–28 days) in the azithromycin group and 11.4±7.8 days (median value 9, range 2 days — 8 weeks) in the doxycycline group (p was isolated from erythema migrans in 28 patients before therapy: in 13 out of 52 in the doxycycline group and in 15 out of 55 in the azithromycin group. Three months after therapy, the culture was positive in four out of 13 patients treated with doxycycline and in one of the 15 patients who received azithromycin. A biopsy was repeated in all the patients with a positive isolation from the first skin specimen. During the first 12 months' follow-up, three patients treated with doxycycline but none in the azithromycin group developed major manifestations of Lyme borreliosis, while 15 doxycycline recipients and 10 azithromycin recipients developed minor consecutive manifestations.

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    We would like to thank Michel J. Belliveau for the comments on our recently published trial1 on comparing the oral Azithromycin with doxycycline. All the. Doxycycline versus Azithromycin for Treatment of Leptospirosis and Scrub Typhus. Kriangsak Phimda, Siriwan Hoontrakul, Chuanpit Suttinont, Sompong. Dec 23, 2015. For several years, the recommended treatment for urogenital infections from Chlamydia trachomatis has been either doxycycline or.

    Belliveau for the comments on our recently published trial(1) on comparing the oral Azithromycin with doxycycline. All the concerns regarding the data presentation are being addressed in the following paragraphs. Belliveau for the comments on our recently published trial(1) on comparing the oral Azithromycin with doxycycline. The null hypothesis had been written in the study design (Clinical Trials.gov; NCT01783860) which was not mentioned in the article because of word number limitation. All the concerns regarding the data presentation are being addressed in the following paragraphs. The null hypothesis had been written in the study design (Clinical Trials.gov; NCT01783860) which was not mentioned in the article because of word number limitation. It was a two-tail hypothesis: "there is not any difference in severity of disease (measured by sign and symptom checklist) at the last follow-up across two groups of treatment (Oral Azithromycin versus Doxycycline)." The sample size calculation was based on the references 12 and 14 of our article which have been cited in the method section. (1) Prior validation is recommended for a questionnaire and not for grading the signs and symptoms of a disease. While a standard questionnaire (like quality of life questionnaire) requires a prior validation because of different subjective feeling and responses to each question, symptom and sign grading could be differently used in different studies based on the aim of study. Seventy-eight adult patients with incluson conjunctivitis were enrolled in this multicenter clinical study. Patients with chlamydial conjunctivitis as indicated by a positive direct fluorescent antibody (DFA) test or cell culture were randomized to receive a single 1-g dose of azithromycin or doxycycline, 100 mg twice daily for 10 days. A conjuctival swab for cell culture was obtained from all patients immediately before the treatment for subsequent confirmation of the presence of chlamydial infection in the central laboratory. Control examinations were performed 10 to 12 days and 4 to 6 weeks after the treatment initiation. Clinical and bacteriological responses to the treatment were evaluated at the last visit. The occurrence and frequency of adverse events were analyzed as well. Of 78 patients enrolled, 51 completed the study and were evaluated for efficacy.

    Azithromycin vs doxycycline

    Azithromycin vs Doxycycline in the Treatment of Non. - SAGE Journals, Doxycycline versus Azithromycin for Treatment of Leptospirosis and.

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  3. Zithromax azithromycin is good for treating many bacterial infections and is available in generic form. However, it may cause headache, dizziness, or rash.

    • Compare Doxycycline vs Azithromycin -.
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    Mar 15, 2008. Background More than 800,000 women in the United States are diagnosed with pelvic inflammatory disease PID during their reproductive. Goal The goal was to perform a meta-analysis to evaluate the efficacy and tolerance of azithromycin versus doxycycline for genital chlamydial infection. Patients were randomized to receive azithromycin a single 1-g dose or doxycycline 100 mg twice daily for 10 days in accordance with the randomization.

     
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