This compound belongs to the class of organic compounds known as aminobenzenesulfonamides. This is an aromatic heteromonocyclic compound that consists of a benzenesulfonamide moiety with an amine group attached to the benzene ring. The detailed chemical classification of Furosemide is as follows: The drug dosage is based on the patient’s medical state, response to treatment, and age. Children dose also includes the parameter of weight. Older people are usually given a lower dose to avoid side effects. Doctor should be consulted regarding side effects for the medical advice. Besides, you or your doctor may report side effects to FDA at 1-800-FDA-1088 or FDA Med Watch Adverse Event Reporting program online at Watch. Some drugs may interact with Furosemide and care should be taken while taking these medications together. It is also used for liver cirrhosis, kidney impairment, nephrotic syndrome, in adjunct therapy for swelling of the brain or lungs where rapid diuresis is required (IV injection), and in the management of severe hypercalcemia in combination with adequate rehydration. Furosemide also can lead to gout caused by hyperuricemia. The tendency, as for all loop diuretics, to cause low serum potassium concentration (hypokalemia) has given rise to combination products, either with potassium or with the potassium-sparing diuretic amiloride (Co-amilofruse). Other electrolyte abnormalities that can result from furosemide use include hyponatremia, hypochloremia, hypomagnesemia, and hypocalcemia. Furosemide, like other loop diuretics, acts by inhibiting the luminal Na-K-Cl cotransporter in the thick ascending limb of the loop of Henle, by binding to the chloride transport channel, thus causing sodium, chloride, and potassium loss in urine. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the corticomedullary osmotic gradient and blocks negative, as well as positive, free water clearance. Because of the large Na Cl absorptive capacity of the loop of Henle, diuresis is not limited by development of acidosis, as it is with the carbonic anhydrase inhibitors. Additionally, furosemide is a noncompetitive subtype-specific blocker of GABA-A receptors. Some of the brand names under which furosemide is marketed include: Aisemide, Apo-Furosemide, Beronald, Desdemin, Discoid, Diural, Diurapid, Dryptal, Durafurid, Edemid, Errolon, Eutensin, Flusapex, Frudix, Frusetic, Frusid, Fulsix, Fuluvamide, Furesis, Furix, Furo-Puren, Furon, Furosedon, Fusid.frusone, Hydro-rapid, Impugan, Katlex, Lasilix, Lasix, Lodix, Lowpston, Macasirool, Mirfat, Nicorol, Odemase, Oedemex, Profemin, Rosemide, Rusyde, Salix, Seguril, Teva-Furosemide, Trofurit, Uremide, and Urex. Ibuprofen 600 mg dosage instructions Sildenafil citrate wiki Chemical structure of furosemide. Click to enlarge. Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up. Antihypertensive; Zerenex Molecular ZBioX-0039 Furosemide Lasix is a loop diuretic inhibitor of Na+/2Cl-/K+ NKCC cotransporter of which used in the treatment of congestive heart failure and edema. Furosemide Lasix Drug Monograph. Special Populations; Pregnancy Rating; Breastfeeding; Chemical Structure; Mechanism of Action; Pharmacodynamics. Furosemide reversibly alters the responses to tones and clicks of the chinchilla basilar membrane in hair cells, causing response-magnitude reductions that are largest (up to 61 d B, averaging 25-30 d B) at low stimulus intensities at the characteristic frequency (CF) and small or nonexistent at high intensities and at frequencies far removed from CF. Furosemide also induces response-phase lags that are largest at low stimulus intensities (averaging 77 degrees) and are confined to frequencies close to CF. Furosemide reversibly suppresses low Ca2 -induced epileptiform activity in hippocampus proper and blocks or significantly reduces different types of epileptiform discharges in the low Mg2 model and the 4-aminopyridine model. Furosemide significantly inhibits cell growth in MKN45 cells, but not in MKN28 cells. Furosemide diminishes cell growth by delaying the G(1)-S phase progression in poorly differentiated gastric adenocarcinoma cells, which show high expression and activity of NKCC, but not in moderately differentiated gastric adenocarcinoma cells with low expression and NKCC activity. Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. Transfer 1m Lof this solution to a flask,add 10m Lof 2.5Nhydrochloric acid,and reflux on a steam bath for 15minutes. Cool,and add 15m Lof 1Nsodium hydroxide and 5m Lof sodium nitrite solution (1in 1000). Allow the mixture to stand for 3minutes,add 5m Lof ammonium sulfamate solution (1in 200),mix,and add 5m Lof freshly prepared Dissolve about 600mg of Furosemide,accurately weighed,in 50m Lof dimethylformamide to which has been added 3drops of bromothymol blue TS,and which previously has been neutralized with 0.1Nsodium hydroxide. Titrate with 0.1Nsodium hydroxide VSto a blue endpoint. Lasix chemical structure Furosemide Ligand page IUPHAR/BPS Guide to PHARMACOLOGY, Furosemide C12H11ClN2O5S ChemSpider Valtrex autismViagra expired Mar 5, 2012. Chemical structure of furosemide. Furosemide - Chemical structure. Gp15DP. Loading. Unsubscribe from Gp15DP? Cancel Unsubscribe. Furosemide - Chemical structure - YouTube. Drug Monograph Furosemide Lasix - EBM Consult. FUROSEMIDE FRUSEMIDE. Chemical information of the drug. Furosemide is a synthetic pharmaceutical organo Aromatic heteromonocyclic compounds named as 4-chloro-2-furan-2-ylmethylamino-5-sulfamoylbenzoic acid. Lasix official prescribing information for healthcare professionals. Includes indications. Chemically, it is 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid. Lasix is available as white. The structural formula is as follows Overview · Side Effects. The flow rate is about 1.0mLper minute. Chromatograph the System suitability solution, and record the peak responses as directed for Procedure the resolution, R, between furosemide and furosemide related compound Ais not less than 2.5;and the relative standard deviation determined from furosemide is not more than 2.0%.