Metformin vs glyburide

Discussion in 'Prescription Drug Assistance' started by shacur, 25-Aug-2019.

  1. Brato Well-Known Member

    Metformin vs glyburide


    A review of recent studies suggests that some oral hypoglycemic agents may be safe and effective in pregnant patients…. Insulin is traditionally the treatment of choice in pregnant patients requiring medication to manage their blood glucose levels, as it is a hormone the body already produces naturally and should therefore theoretically pose less risk to a developing fetus. New evidence, however, suggests that certain oral hypoglycemic agents may be suitable alternatives for these patients. These oral agents would help to simplify medication regimens in many of these patients, as insulin administration is known to be demanding, unpleasant, and inconvenient. A literature search was performed using Pubmed and other electronic databases to identify articles pertaining to this topic. In particular, the keywords pregnancy, diabetes, and the names of different oral hypoglycemic agents were used to find this information. Manufacturers of different oral agents were also contacted for further information. Both glimepiride and glyburide are oral anti-diabetic drugs that belong to the sulfonylureas class of drugs. They act by increasing insulin release from the pancreas, reducing sugar production from the liver, and elevating the sugar uptake sensitivity of the cells throughout the body. They should be taken with breakfast or the first main meal. As with many other oral anti-diabetic drugs, it has been reported that the efficacy of both glimepiride and glyburide decreases over time in a process called secondary failure. As much as 22% of patients undergo secondary failure within the first year of starting these drugs, and this progresses to as much as 50% in the second year. Both glimepiride and glyburide are absorbed rapidly during the first hour, while peak action occurs during the 2nd to 3rd hour. There are some subtle differences when comparing glimepiride and glyburide.

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    Popular Diabetes Drugs Tied to Heart Failure. Metformin was the most widely prescribed drug, followed by second-generation sulfonylureas. and glyburide Diabeta, Micronase, Glycron. This randomized controlled study shows that glyburide and metformin are comparable in management of gestational diabetes. There is. Gestational diabetes is on the increase in the United States. That trend will likely continue if recent recommendations by an international task force are adopted.

    Background: Incidence of gestational diabetes mellitus (GDM) is increasing worldwide. Seshiah V, Balaji V, Balaji MS, Sanjeevi CB, Green A. GDM provides a window of opportunity for the primary prevention of the type 2 diabetes by preventing transgeneration transmission to fetus. Pregnancy and diabetes scenario around the world: India. Insulin in management of GDM has many drawbacks, so use of OHAs has been increased worldwide. Methods: Randomized control trial was performed in patients with GDM who required medical management. Subjects were randomized into two groups and treated with Metformin and Glyburide, results were compared. Summary and recommendations of the fourth International Workshop-Conference on gestational diabetes mellitus. Results: While comparing efficacy of metformin and glyburide in this study for maternal variables; the failure rate of metformin was found to be 9.39 times higher compared to glyburide. Glyburide was associated with 9.5 times more risk to develop hypoglycemia in mother compared to metformin. This randomized controlled study shows that glyburide and metformin are comparable in management of gestational diabetes. There is tendency for metformin to be somewhat superior however, given less insulin use as second line therapy. Objective: To compare the efficacy and safety of glyburide versus metformin and their combination for the treatment of gestational diabetes mellitus (GDM). Research design and methods: In this prospective randomized controlled study, we randomly assigned patients with GDM at 13–33 weeks gestation and whose blood glucose was poorly controlled by diet to receive either glyburide or metformin. If optimal glycemic control was not achieved, the other drug was added. If adverse effects occurred, the drug was replaced. The primary outcomes were the rate of treatment failure and glycemic control after the first-line medication according to mean daily glucose charts. Results: Glyburide was started in 53 patients and metformin in 51.

    Metformin vs glyburide

    A comparative study of metformin and glyburide in gestational., Glyburide vs. Metformin during pregnancy — Gerti Tashko, M. D.

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  6. RESULTS The only significant difference in outcome between the 2 treatment drugs was that maternal weight gain during pregnancy was less in the metformin n=40 than in the glyburide group n=32 10.3 kg vs 7.6 kg; P=0.02.

    • Metformin compared with glyburide for the management of..
    • Is metformin more effective than glyburide for treating gestational..
    • Glyburide/metformin Side Effects, Dosage, Uses, and More.

    Differences between glimepiride vs glyburide. There are some subtle differences when comparing glimepiride and glyburide. Glyburide gained FDA approval in 1984, while glimepiride gained it in 1995. Glyburide and glimepiride have been approved for type 2 diabetes mellitus, but only glyburide has been used for diabetes occurring during pregnancy. Treatment success after second-line therapy was higher in the metformin group than in the glyburide group 13 of 15 87% vs. 9 of 18 50%, respectively; P = 0.03. In the glyburide group, nine 17% patients were eventually treated with insulin compared with two 4% in the metformin group P = 0.03. Glyburide and metformin combination is used to treat a type of diabetes mellitus called type 2 diabetes. It is used together with a proper diet and exercise to help.

     
  7. ger256 New Member

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