Diflucan / Fluconazole is an antifungal medicine which is used in the treatment of thrush, which is a fungal infection. You can take it at any time of day, either before or after a meal. It is prescribed as a single dose for vaginal thrush. To make sure this is the right treatment for you, before you start taking fluconazole it is important that your doctor or pharmacist knows: Thrush Infections The recommended dose is 150mg as a single oral dose. Read the manufacturer's printed information leaflet from inside the pack prior to starting the treatment. Diflucan can be taken at any time of day, and can be taken either before or after a meal. Medical Specialists® are proud of our in-house team of Prescribers, Pharmacists and Experts who carry out the online consultations, dispense medication or help our patients in other ways. If you would like to ask one of our experts any questions regarding your medication or any other matter, then please feel free to submit your query to us and will get back to you. Many yeast infection treatments come in 1-day, 3-day, and 7-day strengths. Over-the-counter vaginal creams and other products you can buy often have the same ingredients to fight a yeast infection as the medication your doctor might prescribe, but in less-concentrated doses. Vaginal creams go inside the vagina to kill off the yeast that cause yeast infections. Sometimes called antifungal creams, these products usually come with an applicator that measure the right dose. Common medicines are: Vaginal creams can be messy and may leak out during the day, so you’ll only want to use them at bedtime. Some of these products may come with a cream that you put on the opening of the vagina and surrounding tissue (called the "vulva") and not into the vagina. 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