Cipro is used to treat a laundry list of bacterial infections, including anthrax, a number of bone and joint infections, and most relevant for travelers, bacterial diarrhea. Widely prescribed for a variety of infections, cipro has lost its potency over recent years. This is what typically happens when bacteria get to face off against an antibiotic with frequency – at some point, a mutated form of the bacteria will emerge and cipro won’t be able to handle it. For now, cipro remains a standard in your travel health arsenal. Read the tips here to better understand where and how to get cipro, and how to take it responsibly. If you are heading to any developing world country, we would strongly recommend bringing it along. If you are traveling to a first world country, you can do without it. It is possible to get a cipro prescription before traveling. If you are taking cipro for the first time, I would schedule a consultation at a travel health clinic. If you are taking other prescription drugs, cipro may interfere with them. , Campylobacter, Shigella, Salmonella, Yersinia and many other species. Fortunately, traveler's diarrhea can usually be avoided by carefully selecting foods and beverages. Although drug prophylaxis is now discouraged, treatment with loperamide (in the absence of dysentery) and a fluoroquinolone, such as ciprofloxacin (500 mg twice daily for one to three days), is usually safe and effective in adults with traveler's diarrhea. Trimethoprim-sulfamethoxazole and doxycycline are alternatives, but resistance increasingly limits their usefulness. Antibiotic treatment is best reserved for cases that fail to quickly respond to loperamide. Nonabsorbable antibiotics, immunoprophylaxis with vaccines and biotherapeutic microbes that inhibit pathogen infection may eventually supplant antibiotic treatment. In the meantime, azithromycin and new fluoroquinolones show promise as possible replacements for the older agents. Ultimately, the best solution is improvements in sanitary engineering and the development of safe water supplies. Travel to destinations such as Latin America, Asia, Africa and the Middle East has never been more popular, with over 20 million travelers visiting a less developed country each year.1 Approximately one third (20 to 50 percent) of travelers to less developed areas of the world become ill from ingesting fecally contaminated food or water.23 In 10 to 20 percent of cases, fever and bloody stools (dysentery) occur.2Although traveler's diarrhea usually resolves within three to five days (mean duration: 3.6 days), in about 20 percent of persons the illness is severe enough to cause bed confinement and in 10 percent of cases the illness lasts more than one week.34 In the very young and the very old, as well as in those who are immunocompromised, traveler's diarrhea can occasionally be life-threatening. 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